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1996-03-09
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Document 0216
DOCN M9650216
TI Immune dysregulation in Ethiopian immigrants in Israel: relevance to
helminth infections?
DT 9605
AU Bentwich Z; Weisman Z; Moroz C; Bar-Yehuda S; Kalinkovich A; R. Ben-Ari
Institute of Clinical Immunology, Kaplan Hospital,; Hebrew University
Hadassah Medical School, Rehovot, Israel.
SO Clin Exp Immunol. 1996 Feb;103(2):239-43. Unique Identifier : AIDSLINE
MED/96152671
AB The infectious disease background and particularly the helminth
infections that are endemic in Africa could have profound effects on the
host immune system. Studies that we have performed on an Ethiopian HIV-
immigrant population that has recently reached Israel, lend support to
this notion. They have indeed revealed a very high prevalence of
helminth and several other infections with an extreme immune
dysregulation, consisting of: (i) highly elevated plasma IgE, IgG,
placental isoferritin, p75 soluble TNF receptor (sTNFR) levels and very
high blood eosinophilia; (ii) increased secretion from
phytohaemagglutinin (PHA)-simulated peripheral blood mononuclear cells
(PBMC) of the cytokines IL-2, IL-4, IL-10 and p75 sTNFR, and decreased
secretion of interferon-gamma (IFN-gamma) and IL-6; (iii) increased and
decreased surface expression of p75 TNFR and IL-6 receptor on
lymphocytes, respectively. The causal relationship between this immune
dysregulation and the infectious background is highly suggestive, and
could have far-reaching implications in the resistance to other
infections.
DE Blacks Cells, Cultured Cytokines/*BIOSYNTHESIS Ethiopia/ETHNOLOGY
Helminthiasis/ETHNOLOGY/*IMMUNOLOGY Human Immunoglobulins/BLOOD
Immunologic Diseases/ETHNOLOGY/EPIDEMIOLOGY/*PARASITOLOGY
Israel/EPIDEMIOLOGY Leukocytes, Mononuclear/*IMMUNOLOGY/PATHOLOGY
Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).